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KMID : 0604520230490030269
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 3 p.269 ~ p.276
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A Study on Anti-inflammatory and Skin Soothing Cosmetics Material of COMPAREX
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Kim Ha-Yeon
Lee Jae
Lee So-Hun
Kim Ye-Hyang
Jeong Eun-Young
Lee Kang-Hyuk
Shin Song-Seok
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Abstract
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Recently, there has been a growing interest in the development of safer and more effective soothing materials to calm skin that has become sensitive to various external factors. The aim of this study was to investigate the skin soothing and anti-inflammatory effects of COMPAREX compared to Portulaca Oleracea extract. The results showed that COMPAREX significantly inhibited LPS-induced NO production and the expression of inflammatory factors iNOS, COX-2, TNF-α, and IL-6 more than P. oleracea extract. In addition, COMPAREX has been confirmed to have a more effective sedative effect by further inhibiting the gene and protein expression of IL-1α against SDS stimulation than the Portulaca Oleracea extract.
Furthermore, COMPAREX inhibited the expression of inflammatory factors COX-2 and IL-8 increased by PM2.5 and suppressed H2O2-mediated carbonylated protein in hair cell. These results suggest that COMPAREX has shown the potential to be used as an improved natural soothing material over P. oleracea extract, and it is expected to be used as a derma cosmetic material in the future.
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KEYWORD
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COMPAREX, skin soothing, anti-inflammation, Portulaca oleracea extract
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